Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism
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چکیده
منابع مشابه
Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention.
Parkinson's disease is a neurodegenerative disorder characterized by oxidative stress and CNS iron deposition. Ceruloplasmin is an extracellular ferroxidase that regulates cellular iron loading and export, and hence protects tissues from oxidative damage. Using two-dimensional electrophoresis, we investigated ceruloplasmin patterns in the CSF of human Parkinson's disease patients. Parkinson's d...
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WILLIAMS, ID. M., G. K. LEE, AND G. E CARTWRIGIIT. Fb-roxidasc nctivity of rat ccruloplasmin. Am. J. Physiol. 227(5) : 1094-1097. 1974.-The ferroxidase activity of rat ceruloplasmin was studied under various assay conditions. The ferroxidase activity was optimal at pH 6.0-6.2 in acetate buffer in the absence of ascorbate, and under these conditions the activity was about 1/3rd that of human cer...
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ceruloplasmin (cp) is a human plasma protein with multiple physiological functions including ferroxidase and oxidase activities. deficiency or inhibition of the enzyme may lead to some abnormalities, including iron deposition in several tissues and causes various pathological conditions in the body. direct interaction of cadmium (cd), a widespread, highly toxic environmental pollutant, with hum...
متن کاملThe inhibition of ferroxidase by trivalent and other metal ions.
The inhibitory effects of trivalent and other metal ions on f erroxidase (ceruloplasmin EC 1.12.3.1.) activity were investigated. All trivalent cations tested inhibited ferroxidase activity but the strongest inhibitors had an ionic radius of 0.81 A or less. The inhibition by Al(III) was found to be mixed competitive and uncompetitive with respect to the substrate, Fe(I1). The uncompetitive feat...
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A new turn-on cell permeable chemodosimetric probe has been developed and its application in the selective detection of trivalent cations (Fe(3+)/Cr(3+)/Al(3+)) at a sub-nanomolar level has been demonstrated. The selectivity of over a broad spectrum of mono- and divalent metal ions was established using fluorescence spectroscopy. Moreover, the changes in the absorption spectra of in the presenc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.2.1116